Krist Neilands was the first rider to withdraw as early as the first day. The Latvian broke his collarbone after the ITT when he returned to the team hotel and crashed. Pre-race favourite Mikel Landa was the second rider who could not continue. The Basque crashed hard in the finale of the 5th stage.
A notable number of stage winners did not reach the finish line in Milan: Merlier, Campenaerts, Dombrowski, Ewan, Mäder, Nizzolo, and Lafay.
DNS in stage 2
47. Krists Neilands (lat – Israel Start-Up Nation)
DNF in stage 5
51. Mikel Landa (spa – Bahrain Victorious)
DNS in stage 6
6. Pavel Sivakov (rus – INEOS Grenadiers)
12. François Bidard (fra – AG2R Citroën)
224. Joe Dombrowski (usa – UAE Emirates)
DNS in stage 7
205. Domenico Pozzovivo (ita – Qhubeka ASSOS)
DNF in stage 8
161. Caleb Ewan (aus – Lotto Soudal)
DNS stage 9
166. Tomasz Marczynski (pol – Lotto Soudal)
DNF in stage 9
14. Clément Champoussin (fra – AG2R Citroën)
56. Matej Mohoric (slo – Bahrain Victorious)
162. Jasper De Buyst (bel – Lotto Soudal)
DNS in stage 11
21. Tim Merlier (bel – Alpecin- Fenix)
DNF in stage 11
103. Jonathan Caicedo (ecu – EF Education-Nippo)
55. Gino Mäder (swi – Bahrain Victorious)
97. Fausto Masnada (ita – Deceuninck-Quick-Step)
145. Alessandro De Marchi (ita – Israel Start-Up Nation)
146. Alex Dowsett (gbr – Israel Start-Up Nation)
164. Kobe Goossens (bel – Lotto Soudal)
171. Marc Soler (spa – Movistar)
DNS in stage 14
154. David Dekker (nld – Jumbo-Visma)
156. Dylan Groenewegen (nld – Jumbo-Visma)
191. Jai Hindley (aus – Team DSM)
DNF in stage 14
84. Nicolas Edet (fra – Cofidis)
165. Roger Kluge (ger – Lotto Soudal)
DNS in stage 15
201. Giacomo Nizzolo (ita – Qhubeka ASSOS)
DNF in stage 15
82. Natnael Berhane (eri – Cofidis)
75. Emanuel Buchmann (ger – BORA-hansgrohe)
105. Ruben Guerreiro (por – EF Education-Nippo)
158. Jos van Emden (nld – Jumbo-Visma)
DNS in stage 16
163. Thomas De Gendt (Lotto Soudal)
DNF in stage 16
126. Sébastien Reichenbach (swi – Groupama-FDJ)
DNS in stage 17
202. Victor Campenaerts (bel – Qhubeka ASSOS)
DNF in stage 17
86. Rémy Rochas (fra – Cofidis)
DNS in stage 18
91. Remco Evenepoel (bel – Deceuninck-Quick-Step)
187. Nick Schultz (aus – Team BikeExchange)
213. Giulio Ciccone (ita – Trek-Segafredo)
DNS in stage 19
31. Jefferson Cepeda (ecu – Androni Giocattoli-Sidermec)
85. Victor Lafay (fra – Cofidis)
DNF in stage 19a>
212. Gianluca Brambilla (ita – Trek-Segafredo)
DNS in stage 20
43. Fabio Felline (ita – Astana)
Last year, 43 riders did not reach the finish in Milano. Geraint Thomas was forced to abandon after a crash in the neutral zone of stage 3, while Simon Yates, Steven Kruijswijk and Michael Matthew tested positive on COVID-19. Subsequently, the entire Jumbo-Visma and Mitchelton-Scott squads pulled out.